Experimental observation of the breaking and recombination of single Cooper pairs

We observe the real-time breaking of single Cooper pairs by monitoring the radio-frequency impedance of a superconducting double quantum dot. The Cooper pair breaking rate in the microscale islands of our device decreases as temperature is reduced, saturating at 2 kHz for temperatures beneath 100 mK. In addition, we measure in real-time the quasiparticle recombination into Cooper pairs. Analysis of the recombination rates shows that, in contrast to bulk lms, a multi-stage recombination pathway is followed.A.J.F. would like to acknowledge the Hitachi Research fellowship, support from Hitachi Cambridge Laboratory and support from the EPSRC grant EP/H016872/1. B.W.L. is supported by a Royal Society University Research Fellowship. F.A.P. would like to thank the Leverhulme Trust for fi nancial support.This is the author accepted manuscript. The final version is available from APS via http://dx.doi.org/10.1103/PhysRevB.90.14050

NRP2 as an Emerging Angiogenic Player; Promoting Endothelial Cell Adhesion and Migration by Regulating Recycling of α5 Integrin.

Angiogenesis relies on the ability of endothelial cells (ECs) to migrate over the extracellular matrix via integrin receptors to respond to an angiogenic stimulus. Of the two neuropilin (NRP) orthologs to be identified, both have been reported to be expressed on normal blood and lymphatic ECs, and to play roles in the formation of blood and lymphatic vascular networks during angiogenesis. Whilst the role of NRP1 and its interactions with integrins during angiogenesis has been widely studied, the role of NRP2 in ECs is poorly understood. Here we demonstrate that NRP2 promotes Rac-1 mediated EC adhesion and migration over fibronectin (FN) matrices in a mechanistically distinct fashion to NRP1, showing no dependence on β3 integrin (ITGB3) expression, or VEGF stimulation. Furthermore, we highlight evidence of a regulatory crosstalk between NRP2 and α5 integrin (ITGA5) in ECs, with NRP2 depletion eliciting an upregulation of ITGA5 expression and disruptions in ITGA5 cellular organization. Finally, we propose a mechanism whereby NRP2 promotes ITGA5 recycling in ECs; NRP2 depleted ECs were found to exhibit reduced levels of total ITGA5 subunit recycling compared to wild-type (WT) ECs. Our findings expose NRP2 as a novel angiogenic player by promoting ITGA5-mediated EC adhesion and migration on FN

Delocalized single-photon Dicke states and the Leggett- Garg inequality in solid state systems

We show how to realize a single-photon Dicke state in a large one-dimensional array of two- level systems, and discuss how to test its quantum properties. Realization of single-photon Dicke states relies on the cooperative nature of the interaction between a field reservoir and an array of two-level-emitters. The resulting dynamics of the delocalized state can display Rabi-like oscillations when the number of two-level emitters exceeds several hundred. In this case the large array of emitters is essentially behaving like a mirror-less cavity. We outline how this might be realized using a multiple-quantum-well structure and discuss how the quantum nature of these oscillations could be tested with the Leggett-Garg inequality and its extensions.Comment: 29 pages, 5 figures, journal pape

Spectral action, Weyl anomaly and the Higgs-Dilaton potential

We show how the bosonic spectral action emerges from the fermionic action by the renormalization group flow in the presence of a dilaton and the Weyl anomaly. The induced action comes out to be basically the Chamseddine-Connes spectral action introduced in the context of noncommutative geometry. The entire spectral action describes gauge and Higgs fields coupled with gravity. We then consider the effective potential and show, that it has the desired features of a broken and an unbroken phase, with the roll down.Comment: 23 pages, 4 figure

Microwave irradiation and quasiparticles in a superconducting double dot

© 2017 American Physical Society. We study the interaction of the charge states of a superconducting double dot, comprising two superconducting islands coupled by a Josephson junction, with microwaves between 2 and 55 GHz. We observe resonant transitions between even-parity charge states at relatively low frequencies and breaking of Cooper pairs under higher-frequency irradiation, allowing our device to act as a click detector for microwave photons. By applying a magnetic field and tuning the pair-breaking energy, we perform spectroscopy on the environment in our cryostat and determine the temperature of a nonequilibrium photon bath. Finally, we exploit the band structure of our device to break Cooper pairs dependent on the symmetry of the initial Cooper pair state

Non-abelian Action for Multiple Five-Branes with Self-Dual Tensors

We construct an action for non-abelian 2-form in 6-dimensions. Our action consists of a non-abelian generalization of the abelian action of Perry and Schwarz for a single five-brane. It admits a self-duality equation on the field strength as the equation of motion. It has a modified 6d Lorentz symmetry. On dimensional reduction on a circle, our action gives the standard 5d Yang-Mills action plus higher order corrections. Based on these properties, we propose that our theory describes the gauge sector of multiple M5-branes in flat space.Comment: LaTeX, 26 pages. v2: improved discussion of Lorentz symmetry. ref added. v3: add comments in the discussion section on the inclusion of scalar fields and supersymmetry; title changed to a more suitable one; version published in JHE

On Non-linear Action for Gauged M2-brane

We propose a non-linear extension of U(1) \times U(1) (abelian) ABJM model including T_{M2} (higher derivative) corrections. The action proposed here is expected to describe a single M2-brane proving C^4/Z_k target space. The model includes couplings with the 3-form background in the eleven-dimensional supergravity which is consistent with the orbifold projection. We show that the novel higgs mechanism proposed by Mukhi and Papageorgakis does work even in the presence of higher derivative corrections and couplings with the background field, giving the correct structure of the Dirac-Born-Infeld action with Wess-Zumino term for a D2-brane. We also find half BPS solutions in the full non-linear theory which is interpreted as an another M2-brane intersecting with the original M2-brane. A possible generalization to U(N) \times U(N) gauge group is briefly discussed.Comment: 19 pages, no figure, references added, typos correcte

Ankyrin-mediated self-protection during cell invasion by the bacterial predator Bdellovibrio bacteriovorus

Predatory Bdellovibrio bacteriovorus are natural antimicrobial organisms, killing other bacteria by whole-cell invasion. Self-protection against prey-metabolizing enzymes is important for the evolution of predation. Initial prey entry involves the predator’s peptidoglycan DD-endopeptidases, which decrosslink cell walls and prevent wasteful entry by a second predator. Here we identify and characterize a self-protection protein from B. bacteriovorus, Bd3460, which displays an ankyrin-based fold common to intracellular pathogens of eukaryotes. Co-crystal structures reveal Bd3460 complexation of dual targets, binding a conserved epitope of each of the Bd3459 and Bd0816 endopeptidases. Complexation inhibits endopeptidase activity and cell wall decrosslinking in vitro. Self-protection is vital — DBd3460 Bdellovibrio deleteriously decrosslink self-peptidoglycan upon invasion, adopt a round morpholog, and lose predatory capacity and cellular integrity. Our analysis provides the first mechanistic examination of self-protection in Bdellovibrio, documents protection-multiplicity for products of two different genomic loci, and reveals an important evolutionary adaptation to an invasive predatory bacterial lifestyle

Towards a tensionless string field theory for the N=(2,0) CFT in d=6

We describe progress in using the field theory of tensionless strings to arrive at a Lagrangian for the six-dimensional $\mathcal N=(2,0)$ conformal theory. We construct the free part of the theory and propose an ansatz for the cubic vertex in light-cone superspace. By requiring closure of the $(2,0)$ supersymmetry algebra, we fix the cubic vertex up to two parameters.Comment: 46 pages, 2 figures. V2: references added; minor changes and improvement